Effects of ischemic preconditioning protocols on skeletal muscle ischemia-reperfusion injury

Kocman E. A., Ozatik O., ŞAHİN A., Guney T., KÖSE A. A., DAĞ İ., ...More

JOURNAL OF SURGICAL RESEARCH, vol.193, no.2, pp.942-952, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 193 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jss.2014.09.032
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.942-952
  • Keywords: Ischemia reperfusion (I/R) injury, Ischemic preconditioning (IPC), Skeletal muscle, LATE-PHASE, NITRIC-OXIDE, RAT MODEL, REMOTE, PROTECTION, FLAP, MECHANISMS, DYSFUNCTION, ACTIVATION, TOLERANCE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background: Ischemic preconditioning (IPC) is described as brief ischemia-reperfusion (I/R) cycles to induce tolerance to subsequent in response to longer I/R insults. Various IPC protocols can be performed in four combinations as follows: at early or late phases and on local or distant organs. Although many experimental studies have been performed on IPC, no consensus has been established on which IPC protocol is most effective. The aims of the present study were as follows: (1) to compare the variables of preconditioning in different combinations (in early versus late phases; local versus remote organ implementations) and (2) to determine the most therapeutic IPC protocol(s).