Comparative genomic hybridization analysis of genomic alterations in benign, atypical and anaplastic meningiomas


Arslantas A., Artan S., Oner U., Durmaz R., Muslumanoglu H., Atasoy M., ...More

ACTA NEUROLOGICA BELGICA, vol.102, no.2, pp.53-62, 2002 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 102 Issue: 2
  • Publication Date: 2002
  • Journal Name: ACTA NEUROLOGICA BELGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.53-62
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background: Meningiomas are common tumors of the central nervous system. Although most are benign tumors, approximately 10% show a histologic progression to a higher malignancy grade similar to atypical (GII) and anaplastic (GIII) meningiomas. Monosomy 22q12 is the most frequent genetic alteration detected in these tumors, but failure of detection of 22q mutations in about 40% of tumors which are indistinguishable from meningiomas with 22q deletions with respect to clinical and histopathologic features, makes it apparent that an alternative mechanism is responsible for the initiation of meningioma. Moreover little is known about genetic alterations during malignant progression of meningioma.