Comparison of the Effects of Curcumin, Tramadol and Surgical Treatments on Neuropathic Pain Induced by Chronic Constriction Injury in Rats.

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Ceyhan D., Kocman A. E., Yıldırım E., Ozatik O., Aydin Ş., Köse A. A.

Turkish neurosurgery, cilt.28, sa.2, ss.288-295, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5137/1019-5149.jtn.19824-17.0
  • Dergi Adı: Turkish neurosurgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.288-295
  • Anahtar Kelimeler: Curcumin, Nerve injury, Neuropathic pain, Surgery, Tramadol, OPIOID RECEPTORS, TNF-ALPHA, MODEL, NERVE, COMBINATION, ASTROCYTES
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

AIM: Nerve entrapment syndromes are the most common causes of neuropathic pain. Surgical decompression is the preferred method of treatment. The aim of this study was to compare the efficacy of curcumin, tramadol and chronic constriction release treatment (CCR), individually or together, in a rat model of sciatic nerve injury.