Warfarin dose requirement in Turkish patients: the influences of patient characteristics and polymorphisms in CYP2C9, VKORC1 and factor VII

Yildirim E., Erol K., Birdane A.

HIPPOKRATIA, cilt.18, sa.4, ss.319-327, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 4
  • Basım Tarihi: 2014
  • Dergi Adı: HIPPOKRATIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.319-327
  • Anahtar Kelimeler: Warfarin, CYP2C9, VKORC1, factor VII, polymorphism, CYTOCHROME P4502C9 POLYMORPHISMS, GENETIC-POLYMORPHISM, DOSING ALGORITHMS, BODY-WEIGHT, FACTOR-II, ANTICOAGULATION, PHARMACOGENOMICS, ASSOCIATION, SENSITIVITY, GENOTYPE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: To determine the contribution of cytochrome P4502C9 (CYP2C9), vitamin K epoxide reductase (VKO-RC1) and factor VII genotypes, age, body mass index (BMI), international normalized ratio (INR) and other individual patient characteristics on warfarin dose requirements in an adult Turkish population.