Synthesis of some thiazolyl-pyrazoline derivatives and preliminary investigation of their hypotensive activity

Turan-Zitouni G., Chevallet P., Kilic F. S., Erol K.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.35, sa.6, ss.635-641, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 6
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1016/s0223-5234(00)00152-5
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.635-641
  • Anahtar Kelimeler: thiazol, pyrazoline, thiazolyl-pyrazoline, chalcone, hypotensive activity, MONOAMINE-OXIDASE, ANTICONVULSANT
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Some 1-(4-arylthiazol-2-yl)-3,5-diaryl-2-pyrazoline derivatives were synthesized by reacting 1-thiocarbamoyl-3,5-diaryl-2-pyrazoline derivatives with phenacetylbromide in ethanol. The structural elucidation of the compounds were performed by IR, H-1-NMR and Mass spectral data and elemental analyses. The hypotensive activities of 13 compounds were evaluated by using the tail-cuff method. All examined compounds showed appreciable hypotensive activities. Clonidine was used as reference substance in the pharmacological evaluation. (C) 2000 Editions scientifiques et medicales Elsevier SAS.