β-Hydroxybutyrate, One of the Three Main Ketone Bodies, Ameliorates Acute Pancreatitis in Rats by Suppressing the NLRP3 Inflammasome Pathway.

Şahin, ERHAN; Bektur Aykanat, N; Kacar, Sedat; Bagci, Rıdvan; Sahinturk, VAROL

doi:10.5152/tjg.2021.191062

β-Hydroxybutyrate, One of the Three Main Ketone Bodies, Ameliorates Acute Pancreatitis in Rats by Suppressing the NLRP3 Inflammasome Pathway.

Şahin E., Bektur Aykanat N. E., Kacar S., Bagci R., Sahinturk V.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, cilt.32, sa.8, ss.702-711, 2021 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 32 Sayı: 8
Basım Tarihi: 2021
Doi Numarası: 10.5152/tjg.2021.191062
Dergi Adı: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.702-711
Anahtar Kelimeler: Acute pancreatitis, NLRP3 inflommasome, beta-hydroxybutyrate, cerulein, PATHOGENESIS, RECEPTORS, CERULEIN, MOLECULE
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: Acute pancreatitis (AP) is a widespread disease resulting from the inflammation of acinar cells in the pancreas. beta-hydroxybutyrate (BHB) is a water-soluble main ketone body synthesized in the human liver. The purpose of this study was to examine the possible therapeutic effects of BNB in the experimentally-induced AP model in rats.