Increased ADMA levels are associated with poor pulmonary outcome in preterm neonates

Kavurt S., Demirel N., BAŞ A. Y., Isik D. U., Ozcan B., AYDEMİR Ö.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, vol.30, no.7, pp.864-869, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 7
  • Publication Date: 2017
  • Doi Number: 10.1080/14767058.2016.1190332
  • Journal Name: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.864-869
  • Keywords: Asymmetric dimethylarginine, prematurity, pulmonary function, NITRIC-OXIDE SYNTHASE, ASYMMETRIC DIMETHYLARGININE, L-ARGININE, BRONCHOPULMONARY DYSPLASIA, RESPIRATORY-DISTRESS, INHIBITOR, INFANTS, DISEASE, BLOOD, LUNG
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background: Nitric oxide (NO), synthesized from the amino acid L-arginine by the action of NO synthases (NOS), is a pulmonary vasodilator. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NOS. Preterm infants have higher plasma ADMA concentrations than term infants which could cause inhibition of NO synthesis and deterioration in pulmonary functions. We aimed to investigate the relationship between serum ADMA and L-arginine levels of preterm infants and respiratory distress syndrome (RDS), requirement of surfactant treatment, duration of mechanical ventilation, oxygen treatment, and development of bronchopulmonary dysplasia (BPD).