Increased ADMA levels are associated with poor pulmonary outcome in preterm neonates

Kavurt S., Demirel N., BAŞ A. Y., Isik D. U., Ozcan B., AYDEMİR Ö.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.30, sa.7, ss.864-869, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 7
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/14767058.2016.1190332
  • Dergi Adı: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.864-869
  • Anahtar Kelimeler: Asymmetric dimethylarginine, prematurity, pulmonary function, NITRIC-OXIDE SYNTHASE, ASYMMETRIC DIMETHYLARGININE, L-ARGININE, BRONCHOPULMONARY DYSPLASIA, RESPIRATORY-DISTRESS, INHIBITOR, INFANTS, DISEASE, BLOOD, LUNG
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: Nitric oxide (NO), synthesized from the amino acid L-arginine by the action of NO synthases (NOS), is a pulmonary vasodilator. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NOS. Preterm infants have higher plasma ADMA concentrations than term infants which could cause inhibition of NO synthesis and deterioration in pulmonary functions. We aimed to investigate the relationship between serum ADMA and L-arginine levels of preterm infants and respiratory distress syndrome (RDS), requirement of surfactant treatment, duration of mechanical ventilation, oxygen treatment, and development of bronchopulmonary dysplasia (BPD).