Comparison of histopathologic classification and surgical stage by cytokeratin 8 and cytokeratin 18 in endometrial cancer

Kabukcuoglu S., Ozalp S. S., YALÇIN Ö. T., Colak E., Abubakar A. A.

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, vol.31, no.6, pp.641-644, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 6
  • Publication Date: 2010
  • Journal Name: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.641-644
  • Keywords: Endometrial cancer, CK8, CK18, Immunohistochemistry, CELL-DEATH, CIRCULATING BIOMARKERS, MICROVESSEL DENSITY, TUMOR, PROTEINS
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Purpose of Investigation The aim of the study was to show the role of the cytoskeletal proteins CK8 and CK18 in endometrial cancer invasion and to histopathologically classify endometrial cancer patients Methods This study was a prospective analysis of 49 histologic samples of consecutively surgically operated endometrial cancer patients After histopathologic classification the most invasive tumor area was selected for immunohistochemistry Monoclonal antihuman keratin Ab 4 and keratin Ab I were applied Results CK8 and CK18 stained tumoral tissue and tumoral cell debris in the lymphovascular space were significantly correlated with stage (p <= 0 005) Conclusions To understand the causes of early treatment failure in endometrial cancer patients further studies are needed to show the role of enhancing factors of endometrial cancer invasion