Use of rotational thromboelastometry for a global screening of coagulation profile in patients of myeloproliferative neoplasms

Sahin D. G., Akay O. M., ÜSKÜDAR TEKE H., ANDIÇ N., GÜNDÜZ E.

PLATELETS, cilt.32, sa.2, ss.280-283, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/09537104.2020.1742309
  • Dergi Adı: PLATELETS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.280-283
  • Anahtar Kelimeler: Essential thrombocythemia, Myeloproliferative neoplasm, Rotational thromboelastography, THROMBOSIS, RISK
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Chronic myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem/progenitor cell characterized by thrombohemorrhagic complications and a tendency to transform into acute leukemia. The pathogenesis of thrombosis in MPN is complex and results from a multifaceted interplay of clinical and disease-related factors. Rotational thromboelastometry (ROTEM) provides the complete and rapid information about all stages of the coagulation process. Here, we assess ROTEM parameters as a screening of coagulation profile in patients with MPNs. In particular, higher mean maximum clot firmness values were found in Essential thrombocythemia and Polycythemia vera patients when compared to healthy controls. Rotational thromboelastometry may be able to detect MPN patients who are susceptible to thrombotic and/or hemorrhagic complications. The predictive value of ROTEM for thrombosis remains to be established to classify subsets of patients at prominent risk who may benefit from prophylaxis with antithrombotic drugs.