Akademik Veri Yönetim Sistemi
JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE, cilt.7, sa.5, ss.639-642, 2016 (ESCI)
Aim: To evaluate the accuracy of current ALT levels in predicting histologically significant liver di 1. 77 +/- 2.61 109 copies/ml (p=0.083). 38.9% of group A patients and 75% of group B patients had histological significant disease (p=0.045). There were no correlations between HBV DNA level and HAI and fibrosis score (respectively (r=-0.133, p=0.45) and (r=-0.259, p=0.14)). Mean histological activity index and fibrosis score were 2.78 +/- 2.31 vs. 4.88 +/- 2.33 (p=0.013) and 0.5 +/- 0.514 vs. 1.31 +/- 1.078 (p=0.007) respectively in group A and B. Five out of 9 group A2 patients (p=0.045) and 2 out of 4 group A4 patients had HAI >= 4. Discussion: ALT level is a good predictor for liver injury. But a cut-off value of 40 IU/L is not the accurate threshold in predicting liver disease probability in children.sease in chronic HBV infected children. Material and Method: Liver biopsies, demographic findings, HBV DNA and ALT levels of HBsAg (+) chronic hepatitis B patients were evaluated retrospectively. Patients were enrolled into group A (ALT< 40) or group B (ALT=40) and further subdivided into males with ALT < 25.8IU/L (A1) and ALT >= 25.8 IU/L (A2) and females with ALT < 22.1 IU/L (A3) and ALT =22.1 IU/L (A4). Significant histology was defined as a fibrosis score >= 2 and/or histological activity index (HAI) >= 4. Results: 34 patients with a mean age of 10.09 +/- 3.59 were included. There were 18 patients in group A and 16 patients in group B. Mean HBV DNA levels were 3.21 +/- 4.41 vs.