Akademik Veri Yönetim Sistemi
38. ULUSAL KARDİYOLOJİ KONGRESİ, Antalya, Türkiye, 10 - 13 Kasım 2022, cilt.26, sa.1, ss.90-91
Background and Aim: Genom-wide association studies have demonstrated that a single nucleotide polymorphism (SNP) at chromosome 4q25 are associated with atrial fibrillation (AF) recurrence after successful direct-current cardioversion (DCCV). However, there is no data related to the genetic predictors of AF recurrence after DCCV in the Turkish population, and there is not enough data related to other SNPs in this topic. We aimed to investigate whether 11 common AF-related SNPs predicted AF recurrence after successful DCCV in Turkish patients (Table 1). Methods: A total of 75 patients with persistent AF who obtained sinus rhythm after DCCV were enrolled in the study. Patients were prospectively followed for AF recurrence after DCCV. Baseline clinical features and SNPs were compared between patients with AF recurrence and those without recurrence. Association between SNPs and AF recurrence was assessed by the additive model (wild type vs. heterozygous variant vs. homozygous variant), dominant model (wild type vs. heterozygous and homozygous variant), and recessive model (homozygous variant vs. heterozygous variant and wild type). Results: AF recurrence developed in 37 patients (50.7%) in the follow-up of 17.0 (11.0-25.0) months. The percentage of female sex was higher (55.3% vs. 32.4%), and AF duration was longer [9.2 (5.5-11.6) vs. 5.0 (2.7-11.0) months] in patients with AF recurrence than in those without recurrence (p=0.046 and 0.027, respectively) (Table 2). Drug use was similar between the groups. One SNP in PITX2 locus (rs17570669_T: OR 9.00, 95% CI 1.28-63.02, p=0.027) and one SNP in ZFHX3 locus (rs2106261_T: OR 8.96, 95% CI 1.03-77.66, p=0.047) were significantly associated with AF recurrence in additive model (Table 1). Cox regression analysis demonstrated that one SNP (rs17570669_T) was found to be independently associated with AF recurrence following DCCV in the additive model (OR: 3.75, 95% CI: 1.10-12.77, p=0.034) (Table 3). A Kaplan-Meier curve showed significantly lower survival without AF recurrence in carriers of the rs17570669_T SNP in the additive model (Figure 1). Conclusions: A SNP in the PITX2 locus (rs17570669_T) is an independent predictor of long-term AF recurrence after successful DCCV in Turkish patients with persistent AF.