Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.41, sa.4, ss.416-423, 2021 (Scopus)
Objective: Cardiological evaluation before transplantation is extremely important in predicting cardiac complications in hematopoietic stem cell transplantation (HSCT) patients. In this study, our aim is to determine the incidence of post-HSCT early cardiac com-plications’ mortality and morbidity and to identify the risk factors which act on the development of cardiac complications. Material and Meth-ods: This study included 218 patients who had undergone HSCT during the time period between January 2014 and January 2020. Patient data were retrospectively retrieved from patient charts and internal elec-tronic record database. Results: Fifty six % (n=122) were males and median age of the cohort was 55 (47-63) years. Eight (3.6%) patients developed Grade III-IV cardiac complications. Patients with ST-T alterations in the pre-transplant electrocardiogram (ECG) had a higher rate of cardiac complications (chi-square, p=0.019). Among the conditioning regimens, cardiac toxicity was determined at a higher rate the group who received melphalan 200 mg/m2 (p=0.040). Conclusion: ST segment and T-wave alterations observed in ECG, pulmonary arterial pressure as measured by electrocardiography and particularly a reading over ˃25 mmHg, utilization of melpahalan 200 mg/m2 as conditioning regimen feature out as the most important risk factors for cardiac complications which may develop subsequent to HSCT.