Probing chromosome structure with dynamic force relaxation

Poirier M. G. , Nemani A., Gupta P., Eroglu S. , Marko J. F.

Physical Review Letters, cilt.86, sa.2, ss.360-363, 2001 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 86 Konu: 2
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1103/physrevlett.86.360
  • Dergi Adı: Physical Review Letters
  • Sayfa Sayıları: ss.360-363


Chromosomes from new epithelial cells (TVI cell line) grown in a monolayer on a small dish were microdissected. The dynamics of stress relaxation in the microdissected chromosomes was characterized. It was found that mitotic chromosomes quickly stretched display well-defined elastic response with a relaxation time on the second time scale. Further, it was observed that loose loop domains are present in physiological conditions.