Probing chromosome structure with dynamic force relaxation

Poirier M. G., Nemani A., Gupta P., Eroglu S., Marko J. F.

Physical Review Letters, vol.86, no.2, pp.360-363, 2001 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 86 Issue: 2
  • Publication Date: 2001
  • Doi Number: 10.1103/physrevlett.86.360
  • Journal Name: Physical Review Letters
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.360-363
  • Eskisehir Osmangazi University Affiliated: No


Chromosomes from new epithelial cells (TVI cell line) grown in a monolayer on a small dish were microdissected. The dynamics of stress relaxation in the microdissected chromosomes was characterized. It was found that mitotic chromosomes quickly stretched display well-defined elastic response with a relaxation time on the second time scale. Further, it was observed that loose loop domains are present in physiological conditions.