Development of an intranasal formulation containing indomethacin and xylometazoline for rhinosinusitis treatment.
European review for medical and pharmacological sciences, cilt.26, sa.2 Suppl, ss.65-71, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 2 Suppl
- Basım Tarihi: 2022
- Doi Numarası: 10.26355/eurrev_202212_30486
- Dergi Adı: European review for medical and pharmacological sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
- Sayfa Sayıları: ss.65-71
- Anahtar Kelimeler: Xylometazoline, Indomethacin, Intranasal Formulation, PERMEATION
- Eskişehir Osmangazi Üniversitesi Adresli: Evet
Özet
OBJECTIVE: Use of the nasal route of drug administration dates back many years and is used both to achieve topical treatments and to allow systemic absorption. The objective was to develop a formulation with novel features which enhance prolonged contact with the nasal and sinusal lining, since this should increase any therapeutic benefit. The anti-inflammatory drug selected was indomethacin, which was combined with xylometazoline, an effective nasal decongestant agent.