Deficiencies of Factor XI (FXID) and Uridine Monophosphate Synthase (DUMPS) are autosomal recessive inherited diseases in Holstein cattle breed. The aim of this study was to investigate whether FXI deficiency and DUMPS alleles exist in Holstein cattle reared in Antalya region Turkey or not. 504 Holstein cows were used for this study. PCR (Polymerase Chain Reaction) was used for determination of FXI genotypes and, PCR-RFLP (PCR- Restriction Fragment Length Polymorphism) was used for determination of DUMPS genotypes. As a result, DUMPS allele was not detected while the prevalence of FXID carriers was found as 0.4%.