Prognostic value of D-dimer/fibrinogen ratio on in-hospital outcomes of patients with heart failure and COVID-19.

Murat S., Murat B., Dural M., Mert G. Ö., Cavusoglu Y.

Biomarkers in medicine, vol.15, no.16, pp.1519-1528, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 16
  • Publication Date: 2021
  • Doi Number: 10.2217/bmm-2021-0341
  • Journal Name: Biomarkers in medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1519-1528
  • Keywords: coronavirus disease, D-dimer, fibrinogen ratio, heart failure, D-DIMER, PULMONARY-EMBOLISM, THROMBOEMBOLISM, GUIDELINES, DIAGNOSIS, ACCURACY
  • Eskisehir Osmangazi University Affiliated: Yes


Aim: In the present study, the relationship between D-dimer/fibrinogen ratio (DFR) and in-hospital outcomes was evaluated in patients with COVID-19 and a diagnosis of heart failure (HF). Materials & methods: In-hospital outcomes were compared in patients with high and low DFR values. Results: With regard to in-hospital outcomes, patients in the third tertile of DFR had a higher rate of mechanical ventilation, cardiogenic shock and death (p < 0.001). The length of ICU stay was longer in the third tertile group (p < 0.001). When evaluated together with infection markers, DFR was found to be an independent predictor of outcomes. Conclusion: DFR can be used as a prognostic marker in patients with COVID-19 with a diagnosis of HF, and perhaps more valuable than other infection markers.