Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives

Sahin, Zafer; Ertas, Merve; BERK, BARKIN; Biltekin, Sevde; YURTTAŞ, LEYLA; DEMİRAYAK, ŞEREF

doi:10.1016/j.bmc.2018.02.048

Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives

Sahin Z., Ertas M., BERK B., Biltekin S. N., YURTTAŞ L., DEMİRAYAK Ş.

BIOORGANIC & MEDICINAL CHEMISTRY, cilt.26, sa.8, ss.1986-1995, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 26 Sayı: 8
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.bmc.2018.02.048
Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1986-1995
Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Steroidal and non-steroidal aromatase inhibitors target the suppression of estrogen biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on developing non-steroidal derivatives for their potential clinical use avoiding steroidal side-effects.