Akademik Veri Yönetim Sistemi
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN, cilt.35, sa.10, ss.1335-1339, 2025 (SCI-Expanded, Scopus)
Objective: To determine the threshold R-hCG values that can predict the live birth (LB) rates in in vitro fertilisation-embryo transfer (IVF-ET) cycles, and to compare these serum R-hCG values separately in fresh and frozen embryo transfers. Study Design: Case-control study. Place and Duration of the Study: Department of Gynaecology and Obstetrics, University of Health Sciences Gulhane Training and Research Hospital, Ankara, Turkiye, between January 2017 and January 2023. Methodology: Serum R-hCG values of patients who underwent single embryo transfer on Day 5 were measured on Days 12 and 14 after transfer. The patients were divided into two groups: pregnancies that resulted in live birth (LB (+)) and pregnancies that did not result in live birth (LB (-)). The two groups were compared in terms of serum R-hCG values and R-hCG increase rates on the 12th and 14th days after transfer. Results: The median R-hCG value measured on day 12 in fresh transfers resulting in LB was found to be 277 IU/L. However, this value was found to be 332 IU/L in frozen transfers. When all transfers were considered without discrimination, it was concluded that the R-hCG test could predict LB with a sensitivity of 75% and a specificity of 72% at a value of 197 IU/L. Conclusion: A cut-off value of 197 IU/L was found to be a strong parameter to predict LB in all transfers, regardless of whether the transfer was fresh or frozen. It will guide clinicians in predicting pregnancy outcomes and counselling patients.