In this study, exponential B-spline collocation method is set up for solving Fisher's equation. Integration of Fisher's equation is managed by use of the exponential cubic B-spline in space and the Crank-Nicolson method in time. The effect of reaction and diffusion is observed by studying three test problems. A comparison is performed between the obtained numerical results and some earlier results using Loo and relative error norms. (C) 2016 Elsevier Ltd. All rights reserved.