Effects of mitochondrial transplantation on chronic pressure wound healing in a human patient
CYTOTHERAPY, cilt.26, sa.6, ss.579-585, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 6
- Basım Tarihi: 2024
- Doi Numarası: 10.1016/j.jcyt.2024.02.027
- Dergi Adı: CYTOTHERAPY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE
- Sayfa Sayıları: ss.579-585
- Eskişehir Osmangazi Üniversitesi Adresli: Hayır
Özet
Background aims: Wound healing is a multistage process that requires a concerted effort of various cell types. The intricate processes involved in the healing of wounds result in high energy requirements. Furthermore, mitochondria play a crucial role in the healing process because of their involvement in neo angiogenesis, growth factor synthesis, and cell differentiation. It is unclear how mitochondria transplantation, a promising new approach, influences wound healing. Methods: In this study, healthy autologous mitochondria obtained from skeletal muscle were injected into chronic pressure wounds as an intervention to promote wound healing. Results: Mitochondrial transplantation accelerated wound healing by reducing wound size, increasing granulation tissue, and hastening epithelialization. Conclusions: This study is the first to demonstrate the therapeutic efficacy of mitochondrial transplantation in wound healing. (c) 2024 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights reserved.