Akademik Veri Yönetim Sistemi
TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.29, sa.1, ss.64-69, 2009 (SCI-Expanded)
Objective: In this study, the clinico-hematological features, the treatment modalities, and the survivals of 130 patients with chronic lymphocytic leukemia (CLL) were evaluated. Material and Methods: The medical records of 130 patients diagnosed with CLL in Eskisehir Osmangazi University Medical Faculty, Department of Internal Medicine, Division of Hematology between 1987 to 2006 were retrospectively evaluated. Results: Eighty five of 130 cases (65%) were men and 45 (35%) were women (male/female ratio, 1.9). The mean age at the time of diagnosis was 64 +/- 0.8 years (range 43-84). Cervical lymph node enlargement was the most common finding. Forty one percent of patients had interstitial bone marrow involvement. Flow cytometric analysis revealed kappa positive CLL in 85/130. During the follow-up period, Richter's syndrome developed in 2 (2%) cases. Sixteen patients were treatment naive for CLL. A response to treatment (complete or partial) was obtained in 58% of patients after initial therapy. Overall survival was 89.7 months in Binet stage A, 77.9 months in stage B and 63.7 months in stage C (p > 0.05). Forty-one (53%) patients died during the follow up. Most of the CLL-related deaths were due to infections (38%) and most of the CLL-unrelated deaths were secondary to cardiovascular causes (30%). Conclusion: The demographic features of our CLL patients were not different from those in other countries. Anemia, thrombocytopenia, elevated white blood cell count, elevated lymphocyte count and elevated bone marrow lymphocyte infiltration were negative prognostic factors since these parameters were significantly common in our late-stage patients.