Polyglandular endocrine failure in a patient with amyloidosis secondary to familial mediterranean fever

Keven K., Oztas E., Aksoy H., Duman N., Erbay B., Erturk S.

AMERICAN JOURNAL OF KIDNEY DISEASES, vol.38, no.6, 2001 (SCI-Expanded) identifier identifier identifier


Familial Mediterranean fever (FMF) is 1 of the major causes of secondary amyloidosis. Renal Involvement Is the main clinical complication and it mostly presents with nephrotic syndrome and chronic renal failure. Although deposition of amyloid has been reported in several endocrine glands such as the adrenal, thyroid, and testes, clinically significant functional impairment is uncommon. Herein, we describe a patient In whom the diagnosis of FMF was based on molecular screening and who presented with recurrent hypoglycemic attacks and extensive amyloid deposition affecting various organ function including adrenal, thyroid, parathyroid, testes, intestinal system, and the heart. (C) 2001 by the National Kidney Foundation, Inc.