Predictive Role of the Systemic Immune-Inflammation Index in Catheter-Related Thrombosis among Neonates: A Retrospective Study

BARSAN KAYA T., ÖZDEMİR Z. C., AYDEMİR Ö., ÖZEN H., ARMAĞAN YALVAÇ S., SÜRMELİ ONAY Ö., ...Daha Fazla

Iranian Journal of Neonatology, cilt.16, sa.3, ss.31-41, 2025 (ESCI)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 3
  • Basım Tarihi: 2025
  • Doi Numarası: 10.22038/ijn.2025.84800.2628
  • Dergi Adı: Iranian Journal of Neonatology
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.31-41
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: This study aimed to evaluate changes in hematological parameters and the systemic immune-inflammation index (SII) to determine their utility in predicting and monitoring catheter-related thrombosis (CRT) in neonatal intensive care unit (NICU). We expect that this study will provide novel insights into the potential role of inflammation-based indices in the management of neonatal thrombosis.

Methods: A retrospective case-control study was conducted in a tertiary NICU over five years. Infants were divided into three groups: those with CRT, those with central venous catheters but without thrombosis (non-CRT), and healthy controls. Serial complete blood counts (CBCs) were analyzed, including inflammatory indices such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and SII.
Results: Compared to the other groups, CRT infants had significantly lower baseline hemoglobin levels and higher levels of white blood cells (WBC), absolute neutrophil count (ANC), NLR, C-reactive protein (CRP), and SII over time (p < 0.05 for all). No significant changes were found in monocyte count, MLR, or mean platelet volume. While SII decreased over time in the control group, it showed a rising trend in CRT infants, indicating ongoing inflammation.
Conclusion: Serial measurements of WBC, ANC, NLR, and SII may serve as useful indicators of thrombotic risk in catheterized neonates. These indices may provide better predictive value than standard CBC parameters. Larger multicenter studies are warranted to validate these findings. Larger multicenter studies are needed to confirm these findings.