Inhalation Therapy of Calcitonin Relieves Osteoarthritis of the Knee
JOURNAL OF KOREAN MEDICAL SCIENCE, cilt.27, sa.11, ss.1405-1410, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 11
- Basım Tarihi: 2012
- Doi Numarası: 10.3346/jkms.2012.27.11.1405
- Dergi Adı: JOURNAL OF KOREAN MEDICAL SCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1405-1410
- Anahtar Kelimeler: Nasal Salmon Calcitonin, Knee Osteoarthritis, Exercise, SALMON-CALCITONIN, ARTICULAR CHONDROCYTES, RADIOGRAPHIC SUBTYPES, EXERCISE THERAPY, II DEGRADATION, MULTIPLE SITES, CARTILAGE, URINARY, BONE, PATHOPHYSIOLOGY
- Eskişehir Osmangazi Üniversitesi Adresli: Evet
Özet
This study was conducted to determine if nasal salmon calcitonin has additional beneficial effects on clinical symptoms, serum NO, IL-1 beta, matrix metalloproteinase 3, urinary C-terminal telopeptide type II collagen (CTX-II) levels and MRI findings in knee osteoarthritis (OA) when used concomitantly with exercise therapy. Fifty female patients with knee OA were randomized into two groups. The first group (n = 30) received 200 IU/day nasal salmon calcitonin and a home exercise program; the second group (n = 20) received a home exercise program for 6 months. Compared with baseline, while significant improvements were observed in visual analogue scale (VAS), WOMAC pain, physical function scores, 20-m walking time (P<0.001) and WOMAC stiffness score (P=0.041) in the first group, walking and resting VAS, and WOMAC physical function scores were improved (P=0.029) in the second group after treatment. Significantly increased levels of serum NO and urinary CTX-II (P<0.001) and significant improvements in the area of medial femoral condyle (P<0.05) were noted only in the first group. There were significant differences in VAS activation values (P=0.032) and NO levels (P<0.001) in the favor of the first group. In conclusion, nasal salmon calcitonin may have possible chondroprotective effects besides its known effects on symptoms in patients with knee OA.