Study on potential role of apolipoprotein E in recurrent pregnancy loss

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Korkmazer E., Ustunyurt E., Tekin B., ÇİLİNGİR O.

EXPERIMENTAL AND THERAPEUTIC MEDICINE, cilt.5, sa.5, ss.1408-1410, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3892/etm.2013.997
  • Dergi Adı: EXPERIMENTAL AND THERAPEUTIC MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1408-1410
  • Anahtar Kelimeler: apolipoprotein E, polymorphism, pregnancy, recurrent pregnancy loss, THROMBOPHILIC GENE-MUTATIONS, EPSILON-4 ALLELE, PREECLAMPSIA, ASSOCIATION, RISK
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

The role of apolipoprotein E (Apo E) gene polymorphisms in the etiology of recurrent pregnancy loss (RPL) is not clearly understood. We evaluated this polymorphism in unexplained pregnancy losses in a group of Turkish women. In our prospective case-control study, 45 well-characterized RPL cases were examined for their Apo E genotypes, based on restriction fragment length polymorphism analysis of polymerase chain reaction (PCR)-amplified fragments. The observed genotypes were compared with those obtained from equal number matched controls. We observed similar Apo E genotypes and E2, E3 and E4 allele frequency distribution among RPL patients and controls. The allele frequencies obtained in patients and controls, respectively, were as follows: E2=8 (9%) and 12 (13.4%) (P=0.342), E3=66 (73.3%) and 60(66.6%) (P=0.328) and E4=16 (17.7%) and 18 (20%) (P=0.703). Our data did not support the association of Apo E gene polymorphisms with RPL as reported by previous studies. We endorse adequate characterization of RPL cases and adequate sample size prior to addressing such studies.