Antibacterial and antifungal activities of some trimethoprim salts


TUNALI Y., KARACA GENÇER H., İŞCAN G., DEMİRCİ F., BENKLİ K.

MEDICINAL CHEMISTRY RESEARCH, vol.21, no.6, pp.932-935, 2012 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1007/s00044-011-9605-5
  • Title of Journal : MEDICINAL CHEMISTRY RESEARCH
  • Page Numbers: pp.932-935

Abstract

In this study, the antimicrobial activities of Trimethoprim (1), Trimethoprim + Maleic acid (2), Trimethoprim + Oxalic acid dihydrate (3), and Trimethoprim + trans-1,2-Cyclohexanedicarboxylic acid (4) were investigated for their in vitro growth inhibitory activity against human pathogenic as some bacteria and fungi. Substances were tested using the micro-broth dilution assay. The chemical agents showed the same activity against Escherichia coli, Pseudomonas aeruginosa, and Proteus vulgaris. Inhibitory activities of test chemicals against different Candida strains were determined to be widely moderate.