The Complete Success in Refractory Mooren’s Ulcer Treated with Infliximab

Çakmak A. İ., Akova Y., YILDIRIM N.

Ocular Immunology and Inflammation, cilt.31, sa.4, ss.682-688, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Kısa Makale
  • Cilt numarası: 31 Sayı: 4
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/09273948.2022.2091615
  • Dergi Adı: Ocular Immunology and Inflammation
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.682-688
  • Anahtar Kelimeler: Anti-tumor necrosis factor alpha, immunosuppresion, infliximab, Mooren's ulcer, peripheral ulcerative keratitits, PATIENT
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

© 2022 Taylor & Francis Group, LLC.Purpose: To describe the management and outcome of two extremely rare and painful cases of Mooren’s ulcer, an idiopathic peripheral autoimmune-associated ulcerative corneal disease. Methods: Case report with literature review on the management of ocular inflammation in Mooren’s ulcer. Results: A 47-year-old female and a 76-year-old female presented with progressive bilateral Mooren’s ulcer that were refractory to conventional immunosuppressive therapy. Following treatment with infliximab, an anti-tumor necrosis factor alpha, a significant improvement in disease progression was observed, with no corneal thinning or perforation at follow-ups. Conclusion: This case report highlights how infliximab can be effective in cases with Mooren’s ulcer refractory to conventional therapies.