© 2022 Taylor & Francis Group, LLC.Purpose: To describe the management and outcome of two extremely rare and painful cases of Mooren’s ulcer, an idiopathic peripheral autoimmune-associated ulcerative corneal disease. Methods: Case report with literature review on the management of ocular inflammation in Mooren’s ulcer. Results: A 47-year-old female and a 76-year-old female presented with progressive bilateral Mooren’s ulcer that were refractory to conventional immunosuppressive therapy. Following treatment with infliximab, an anti-tumor necrosis factor alpha, a significant improvement in disease progression was observed, with no corneal thinning or perforation at follow-ups. Conclusion: This case report highlights how infliximab can be effective in cases with Mooren’s ulcer refractory to conventional therapies.