Akademik Veri Yönetim Sistemi
TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.31, sa.5, ss.1057-1064, 2011 (SCI-Expanded)
Objective: In our study we aimed to immunohistochemically investigate p53, bcl-2 and nm23 expressions in mucinous ovarian tumors and to detect whether there was a difference among benign, borderline and malignant tumors in terms of expression. It was aimed to determine the relationship between stage, age, tumor size, omentum involvement, presence of malignant cells in peritoneal fluid and some histopathological parameters (grade, mitotic count, nuclear pleomorphism, growth pattern) in malignant tumors and p53, bcl-2 and nm23 expressions. Material and Methods: A total of 47 mucinous ovarian tumor cases that were diagnosed in Pathology Department of Ankara Numune Research and Training Hospital were enrolled in the study. Tumors were grouped as malignant, borderline and benign. P53, bcl-2 and nm23 were studied immunohistochemically in the paraffin block reflecting the morphology best. Staining more than 1% was accepted as positive. If staining was 1-10%, it was scored as (+), 11-50%, it was scored as (++) and if more than 50%, it was scored as (+++). Results: p53 expression was detected to be absent in benign tumors, as 9.1% in borderline tumors and 7.7% positive in mucinous carcinomas. Bcl-2 expression was found as 39.1%, 36.4% and 30.8% respectively in benign, borderline and malignant tumors. nm23 was expressed as 52.2% in benign tumors, 81.8% in borderline tumors and 84.6% in carcinomas. Conclusion: p53 was seen not to have a role in pathogenesis or carcinogenesis of mucinous tumors. A statistically significant difference was not found in bcl-2 expression of mucinous ovarian tumors. Higher expression of the nm23 in advanced stage and high grade carcinomas suggests that nm23 acts as oncogene in these tumors. In mucinous carcinomas, a significant difference was not found between groups with or without p53, nm23, bcl-2 expression in terms of age, tumor size, bilaterality, omentum involvement, presence of malignant cells in peritoneal fluid and histopathological parameters (growth pattern, pleomorphism, mitotic count).