Akademik Veri Yönetim Sistemi
PHARMACEUTICAL BIOLOGY, cilt.44, sa.9, ss.660-667, 2006 (SCI-Expanded, Scopus)
In this study, we have investigated the antimicrobial activities of intracellular and/or extracellular metabolites of some mushrooms such as Amanita caesarae (Scop.: Fr.) Pers., Armillaria mellea (Vahl) P. Kumm., Chroogomphus rutilus (Schaeff.) O.K. Mill., Clavariadelphus truncatus (Quel.) Donk., Clitocybe geotropa (Bull.) Quel., Ganoderma sp., Ganoderma carnosum Pat., Hydnum repandum L., Hygrophorus agathosmus (Fr.) Fr., Lenzites betulina (L.) Fr., Lepista nuda (Bull.) Cooke, Leucoagaricus pudicus (Bull.) Bon, Paxillus involutus (Batsch) Fr., Polyporus arcularius (Batsch) Fr., Rhizopogon roseolus (Corda) Th.Fr., Sarcodon imbricatus (L.) P. Karst., Suillus collitinus (Fr.) O. Kuntze., Trametes versicolor (L.) Lloyd, Tricholoma auratum (Paulet) Gillet, and Tricholoma fracticum (Britzelm.) Kreisel. Antimicrobial activities of these mushroom extracts were examined on test microorganisms Escherichia coli ATCC 25922, Enterobacter aerogenes NRRL-B-3567, Salmonella typhimurium NRRL-B-4440, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 25923, Staphylococcus epidermidis NRRL-B-4377, Bacillus subtilis NRRL-B-558, Candida albicans ATCC 10259, and Saccharomyces cerevisiae NRRL-Y-2034 by the disk diffusion and microdilution methods. The chloroform extract of Hygrophorus agathosmus and the dichloromethane extract of Suillus collitinus were the most active extracts against both yeast and bacteria. MIC values of these extracts were detected between 7.81 and 250 mu g/mL for Hygrophorus agathosmus and between 31.25 and 250 mu g/mL for Suillus collitinus. Antimicrobial activity was mostly static. Substances responsible for the antimicrobial activity were heat-stable.