Spectroscopic determination of acid dissociation constants of some imidazole derivatives

Ogretir C., Berber H., Asutay O.

JOURNAL OF CHEMICAL AND ENGINEERING DATA, vol.46, no.6, pp.1540-1543, 2001 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 6
  • Publication Date: 2001
  • Doi Number: 10.1021/je0100802
  • Journal Name: JOURNAL OF CHEMICAL AND ENGINEERING DATA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1540-1543
  • Eskisehir Osmangazi University Affiliated: No

Abstract

The acid dissociation constants, pK(a), of eight biologically active imidazole derivatives were determined using a spectroscopic technique. Using the obtained acid dissociation constants, attempts were made to elucidate the structures and protonation mechanisms of these derivatives. Four of eight molecules were found to behave as Hammett base for the first protonation.