Spectroscopic determination of acid dissociation constants of some imidazole derivatives

Ogretir C., Berber H., Asutay O.

JOURNAL OF CHEMICAL AND ENGINEERING DATA, cilt.46, sa.6, ss.1540-1543, 2001 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 6
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1021/je0100802
  • Dergi Adı: JOURNAL OF CHEMICAL AND ENGINEERING DATA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1540-1543
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

The acid dissociation constants, pK(a), of eight biologically active imidazole derivatives were determined using a spectroscopic technique. Using the obtained acid dissociation constants, attempts were made to elucidate the structures and protonation mechanisms of these derivatives. Four of eight molecules were found to behave as Hammett base for the first protonation.