Enhancement in dissolution pattern of piribedil by molecular encapsulation with beta-cyclodextrin


Demirel M., Buyukkoroglu G., Kalava B., Yazan Y.

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, vol.28, no.2, pp.83-88, 2006 (SCI-Expanded) identifier identifier identifier

Abstract

The aim of this was to improve the dissolution behavior of piribedil by molecular encapsulation with beta-cyclodextrin (beta-CD). Toward this aim, physical mixing, co-grinding, and spray-drying methods were used to prepare solid binary sytems. Differential scanning calorimetry, X-ray diffractomertry, and particle size analysis were used to characterize the binary systems obtained. Complexes of piribedil and beta-CD could be prepared using the spray-drying method. Dissolution of piribedil was improved to a great extent by the complex prepared. (c) 2006 Prous Science. All rights reserved.