Differentiation Potential of Mouse Embryonic Stem Cells into Insulin Producing Cells in Pancreatic Islet Microenvironment

Yilmaz I., EKER SARIBOYACI A., Subasi C., Karaoz E.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, cilt.124, sa.2, ss.120-129, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 124 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1055/s-0035-1554720
  • Dergi Adı: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.120-129
  • Anahtar Kelimeler: differentiation, co-culture, microenvironment, mouse pancreatic islets, embryonic stem cells, insulin producing cells, BETA-CELLS, ENDOCRINE PANCREAS, IN-VITRO, REGENERATION, EXPRESSION, GENERATION, MAFA, THERAPY, ACTIVIN
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Background: The differentiation capacity of embryonic stem cells (ESCs) has great promise for type-1 diabetes for cellular treatment. Therefore, different strategies have been reported so far for derivation of insulin producing cells (IPCs) from ESCs. Providing similar microenvironmental conditions as in vivo, functional differentiation of stem cells into desired cell types could be obtained in vitro. The aim of the present research was to utilize differentiation potential of ESCs to IPCs by co-culture with mouse pancreatic islets (mPIs) for the first time.