The coexistence of IgA vasculitis and tuberculosis: a case-based review

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YILDIRIM R., Cansu D. U., Uludogan B. C. E., Dinler M., TEKİN E., KORKMAZ C.

RHEUMATOLOGY INTERNATIONAL, vol.41, no.9, pp.1683-1689, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 41 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.1007/s00296-021-04922-3
  • Journal Name: RHEUMATOLOGY INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1683-1689
  • Keywords: Tuberculosis, Anti-tubercular agents, Henoch-Schonlein purpura, IgA vasculitis, CUTANEOUS LEUKOCYTOCLASTIC VASCULITIS, HENOCH-SCHONLEIN PURPURA, RARE ASSOCIATION, GRANULOMATOSIS, NEPHROPATHY
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Immunoglobulin (Ig) A vasculitis (IgAV), formerly known as Henoch-Schonlein purpura (HSP), is a relatively uncommon form of vasculitis primarily targeting the skin, gastrointestinal system, and the kidneys. Although the pathogenesis has not yet been well identified, several triggering factors, such as infections, drugs, have been implicated in the development of IgAV. Tuberculosis (TB), albeit rare, may precipitate IgAV. Herein, we have presented a case manifested by purpuric skin rash and proteinuria 6 weeks following diagnosis of pulmonary tuberculosis while receiving anti-TB drugs. The case was diagnosed as having active tuberculosis and TB-related IgA vasculitis with multi-organ involvement. In this case-based review, we recruited cases with TB-related Ig A vasculitis from the literature and discussed the features of tuberculosis that mimic vasculitides and vice versa. We also discussed the difficulties in diagnosis and the therapeutic approach in the light of the literature.