In Vivo Assessment of the Effect of Hexagonal Boron Nitride Nanoparticles on Biochemical, Histopathological, Oxidant and Antioxidant Status


KAR F., HACIOĞLU C., GÖNCÜ Y., Sogut I., ŞENTÜRK H., BURUKOĞLU DÖNMEZ D., ...More

JOURNAL OF CLUSTER SCIENCE, vol.32, no.2, pp.517-529, 2021 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1007/s10876-020-01811-w
  • Journal Name: JOURNAL OF CLUSTER SCIENCE
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, Metadex, DIALNET, Civil Engineering Abstracts
  • Page Numbers: pp.517-529
  • Keywords: Hexagonal boron nitride, Rat, Serum, Cytotoxicity, Oxidative stress, POTENTIAL APPLICATIONS, GLYCOL-CHITOSAN, NANOTUBES, TOXICITY, CYTOCOMPATIBILITY, BIOCOMPATIBILITY

Abstract

The aim of our study is to investigate the dose-dependent biological system effect of hexagonal boron nitride (hBN) nanoparticles, which is directly produced nanoscale, in vivo. Wistar albino rats (n = 80) weighing 200-250 g were divided into eight groups (n = 10). The acute effects of hBN NPs (i.v) on the rats were investigated by measuring the biochemical, hematological parameters and oxidant-antioxidant status. The results show that no significant change was observed in the hematological and biochemical parameters when the control group and other low dose groups were compared, except for the 1600 and 3200 mu g/kg b.w. dose groups. Histological detection indicated that 1600 and 3200 mu g/kg hBN NPs treatment could induce significant damage in the liver, kidney, heart, spleen and pancreas. With the findings obtained, it can be seen that hBN NPs cannot be evaluated independently of particle morphology, and that the hBN NPs used in this study may be suitable for biomedical applications where low doses between 50 and 800 mu g/kg are not toxic.