Akademik Veri Yönetim Sistemi
Heart Failure 2021 Online Congress, 29 Haziran - 01 Temmuz 2021, ss.5
Poor prognostic biomarkers in heart failure patients hospitalized with covid
19; a propensity score-matched analysis
S Murat1; B Murat2; FE Durmaz1; Y Cavusoglu1; 1Eskisehir Osmangazi University,
Cardiology, Eskisehir, Turkey; 2Eskisehir City Hospital, Cardiology, Eskisehir, Turkey;
Funding Acknowledgements: Type of funding sources: None.
Background: Coronavirus disease 2019 (COVID-19) has resulted in considerable
morbidity and mortality worldwide since December 2019. Several poor prognostic
biomarkers including cardiac troponin (cTn), D-dimer, ferritin, C-reactive protein
(CRP), lactate and procalcitonin have been reported to be associated with worse
clinical outcomes in patients with COVID-19.
Purpose: In this study, we aimed to examine the levels of poor prognostic biomarkers
and in-hospital clinical outcomes in patients with heart failure (HF) who were
hospitalized for COVID-19.
Methods: The study enrolled 3849 consecutive patients hospitalized for COVID-19
in two centers, between March 15, 2020 and December 01, 2020. After a propensity
score matching for the variables of age, sex, hypertension, diabetes mellitus and
coronary artery disease, 240 patients with HF and 240 patients without HF were
matched. We compared poor prognostic biomarker levels between these two
groups. Additionally, composite outcome of death from any cause, mechanical
ventilation and cardiogenic shock, and also, each component of composite outcome
has been examined.
Results: Mean age of the study population was 72.7±9.9 years old. Patients
with HF, compared to those without HF, had significantly higher leukocyte count
(p<0.001), cTnT (p <0.001) D-dimer (p< 0.001), CRP (p<0.001), sedimentation rate
(p <0.017), procalcitonin (p<0.001), ferritin (p <0.001) and lactate levels (p<0.001)
(Table 1). Also, HF patients had a higher rate of mechanical ventilation (101 (42.1%).