The utility of thromboelastometry in prophylactic platelet transfusion for hematological malignancies

Akay O. M., Sahin D. G., ANDIÇ N., GÜNDÜZ E., Karagulle M., ÇOLAK E., ...Daha Fazla

TRANSFUSION AND APHERESIS SCIENCE, cilt.53, sa.1, ss.64-68, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.transci.2015.03.008
  • Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.64-68
  • Anahtar Kelimeler: Platelet, Thromboelastometry, Transfusion, RANDOMIZED CONTROLLED-TRIAL, ACUTE-LEUKEMIA, CLINICAL-PRACTICE, FACTOR-VIIA, IN-VITRO, PLASMA, CANCER, THROMBOCYTOPENIA, RECOMMENDATIONS, COAGULATION
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

There is still debate on how, platelet transfusions should be used to prevent severe bleeding. The aim of our study is to assess the clinical efficacy of thromboelastometry in reducing number of prophylactic platelet transfusions in patients with hematological malignancies. One hundred hematological malignancy patients were included in the study. Six units random donor platelets (RDPs) was given to the first group, three units RDPs was given to the second group, one unit single donor platelets (SDPs) was given to the third group, and 1/2 unit SDPs was given to the fourth group. Before and 15 minutes after transfusion, rotation thromboelastometry (ROTEM) was performed (Pentapharm GmbH, Munich, Germany). ROTEM parameters did not show any statistical difference between 'low dose' and 'high dose' random or single donor platelet transfusions. Therefore, low dose platelet transfusion can be considered because of its reduced adverse transfusion reactions and economic burden. (C) 2015 Elsevier Ltd. All rights reserved.