Synthesis, characterization, antimicrobial and antifungal activity studies of two novel aminopyridine-sulfamoylbenzoic acid salts and their Cu(II) complexes

İLKİMEN H., Turken N., Gulbandilar A.

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, cilt.18, sa.8, ss.1941-1946, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 8
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s13738-021-02157-4
  • Dergi Adı: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.1941-1946
  • Anahtar Kelimeler: Sulfamoylbenzoic acid, 2-Amino-3-methylpyridine, Cu(II) complex, Antibacterial activity, Antifungal activity
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Two new proton transfer compounds, (H2a3mp)(+)(psba)(-) (1) and (H2a3mp)(+)(2MeO5sba)(-) (2), obtained from 2-amino-3-methylpyridine with (2a3mp) and p-sulfamoylbenzoic acid (Hpsba) or 2-methoxy-5-sulfamoylbenzoic acid (H2MeO5sba), respectively, and Cu(II) complexes of Hpsba (3), of H2MeO5sba (4), of 1 (5) and of 2 (6) were synthesized and characterized by FT-IR, UV, H-1-NMR, elemental, AAS, magnetic measurement and molar conductivity. Furthermore, free compounds, 2a3mp, Hpsba, 2MeO5sba and Cu(CH3COO)(2)center dot H2O, Cu(II) complex of 2a3mp (Cu2a3mp) and compounds (1-6) have been screened for their antifungal and antibacterial activities against Candida parapisilosis (ATCC 22019), Candida krusei (ATCC 6258) (yeast) and Enterococcus faecalis (ATCC 29212) Escherichia coli (ATCC 25922) (Gram negative), Staphylococcus aureus (ATCC 29213) (Gram positive). The results are touched with standard antifungal agent (Fluconazole) and antibacterial agents (Cefepime, Vancomycin and Levofloxacin).