The Role of Cyclooxygenase Enzymes in the Effects of Losartan and Lisinopril on the Contractions of Rat Thoracic Aorta

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Özatik F. Y., Kaygısız B., Erol K.

EURASIAN JOURNAL OF MEDICINE, vol.49, pp.16-21, 2017 (ESCI, Scopus, TRDizin)

  • Publication Type: Article / Article
  • Volume: 49
  • Publication Date: 2017
  • Doi Number: 10.5152/eurasianjmed.2017.16254
  • Journal Name: EURASIAN JOURNAL OF MEDICINE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.16-21
  • Keywords: Cyclooxygenase, dipyrone, lisinopril, losartan, thoracic aorta, ANGIOTENSIN-II, RENOVASCULAR HYPERTENSION, ENDOTHELIAL DYSFUNCTION, VASCULAR-RESPONSES, SMOOTH-MUSCLE, EXPRESSION, RECEPTOR, DRUGS, ACETAMINOPHEN, PHENYLEPHRINE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Objective: It was suggested that prostaglandins which are synthesized by cyclooxygenase (COX) enzymes contribute to the actions of angiotensin-converting enzyme (ACE) inhibition and angiotensin AT1 receptor antagonism and there is an interaction between ACE signaling pathway and COX enzymes. We aim to investigate the role of COX enzymes in the effects of losartan, an angiotensin II (Ang II) receptor antagonist or lisinopril, an ACE inhibitor, on the contractions of rat thoracic aorta in isolated tissue bath.