AN EARLY DIAGNOSTIC TOOL FOR DIABETIC NEUROPATHY: CONDUCTION VELOCITY DISTRIBUTION

TUNCER S., Dalkilic N., Esen H. H., Avunduk M. C.

MUSCLE & NERVE, cilt.43, sa.2, ss.237-244, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1002/mus.21837
  • Dergi Adı: MUSCLE & NERVE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.237-244
  • Anahtar Kelimeler: compound action potential, diabetic peripheral neuropathy, nerve conduction velocity distribution, rat, sciatic nerve, NERVE-CONDUCTION, MOTOR CONDUCTION, FIBER
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Diabetes is a metabolic disorder that. affects much of the human population. As a secondary complication, diabetic neuropathy causes time-dependent damage to peripheral nerves. In this study, experimental diabetes was induced by streptozotocin (STZ; 50 mg/kg intraperitoneally) in rats. Diabetic animals were grouped into those with 2 or 4 weeks of diabetes, whereas a control group received only the STZ vehicle (0.1 M citrate). Sciatic nerves were dissected, and compound action potentials (CAPS) were recorded. Results deduced by conventional calculation carried less information when compared with conduction velocity distribution (CVD) obtained by a computer-based mathematical model. Using the conventional approach, statistically significant changes were first seen in the fourth week of diabetes, whereas results deduced by CVD measurement could be seen in the second week. Consequently, the CVD calculation provides more information for the early diagnosis of neuropathies compared with classical conduction velocity measurements. Muscle Nerve 43: 237-244, 2011