Copy For Citation
Kaygısız B., Kılıç F. S., Senguleroglu N., Baydemir C., Erol K.
PHARMACOLOGICAL REPORTS, vol.67, pp.129-133, 2015 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
67
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Publication Date:
2015
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Doi Number:
10.1016/j.pharep.2014.08.013
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Journal Name:
PHARMACOLOGICAL REPORTS
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.129-133
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Keywords:
Pregabalin, Experimental pain, L-NAME, Cyproheptadine, Naloxone, SENSITIVE K+ CHANNELS, HOT-PLATE TEST, NEUROPATHIC PAIN, GABAPENTIN, MODEL, ACID, RAT, NOCICEPTION, ACTIVATION, MORPHINE
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Eskisehir Osmangazi University Affiliated:
Yes
Abstract
Background: Pregabalin, a potent anticonvulsant agent, is used in treatment-resistant epileptic patients. It is reported that pregabalin also has analgesic effect in different pain syndromes. However, there is limited data on its antinociceptive mechanisms of action. We aimed to investigate the central and peripheral antinociceptive effects of pregabalin and the contribution of nitrergic, serotonergic, and opioidergic pathways in mice.