The antinociceptive effect and mechanisms of action of pregabalin in mice

Kaygısız B., Kılıç F. S., Senguleroglu N., Baydemir C., Erol K.

PHARMACOLOGICAL REPORTS, cilt.67, ss.129-133, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.pharep.2014.08.013
  • Dergi Adı: PHARMACOLOGICAL REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.129-133
  • Anahtar Kelimeler: Pregabalin, Experimental pain, L-NAME, Cyproheptadine, Naloxone, SENSITIVE K+ CHANNELS, HOT-PLATE TEST, NEUROPATHIC PAIN, GABAPENTIN, MODEL, ACID, RAT, NOCICEPTION, ACTIVATION, MORPHINE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: Pregabalin, a potent anticonvulsant agent, is used in treatment-resistant epileptic patients. It is reported that pregabalin also has analgesic effect in different pain syndromes. However, there is limited data on its antinociceptive mechanisms of action. We aimed to investigate the central and peripheral antinociceptive effects of pregabalin and the contribution of nitrergic, serotonergic, and opioidergic pathways in mice.