The antinociceptive effect and mechanisms of action of pregabalin in mice

Kaygısız B., Kılıç F. S., Senguleroglu N., Baydemir C., Erol K.

PHARMACOLOGICAL REPORTS, vol.67, pp.129-133, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67
  • Publication Date: 2015
  • Doi Number: 10.1016/j.pharep.2014.08.013
  • Journal Name: PHARMACOLOGICAL REPORTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.129-133
  • Keywords: Pregabalin, Experimental pain, L-NAME, Cyproheptadine, Naloxone, SENSITIVE K+ CHANNELS, HOT-PLATE TEST, NEUROPATHIC PAIN, GABAPENTIN, MODEL, ACID, RAT, NOCICEPTION, ACTIVATION, MORPHINE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background: Pregabalin, a potent anticonvulsant agent, is used in treatment-resistant epileptic patients. It is reported that pregabalin also has analgesic effect in different pain syndromes. However, there is limited data on its antinociceptive mechanisms of action. We aimed to investigate the central and peripheral antinociceptive effects of pregabalin and the contribution of nitrergic, serotonergic, and opioidergic pathways in mice.