Investigation of endoplasmic reticulum stress and sonic hedgehog pathway in diabetic liver injury in mice

ŞAHİNTÜRK V., KAÇAR S., ŞAHİN E., Aykanat N. E. B.

LIFE SCIENCES, vol.246, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 246
  • Publication Date: 2020
  • Doi Number: 10.1016/j.lfs.2020.117416
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Diabetes, Liver, Sonic hedgehog, Endoplasmic reticulum stress, OXIDATIVE STRESS, ANTIOXIDANT STATUS, SIGNALING PATHWAY, CELL FUNCTION, ER STRESS, EXPRESSION, MELLITUS, HYPERGLYCEMIA, ACTIVATION, MECHANISMS
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Aims: Diabetes is a common metabolic disease which damages many organs including the liver and causes endoplasmic reticulum (ER) stress, which originates from non-folded proteins. Sonic hedgehog (Shh) pathway plays a role in liver regeneration and repair. To our knowledge, there is no study showing the relation between ER stress and Shh pathway in the liver in diabetes. Thus, the aim of this study was to investigate the interaction between ER stress and Shh pathway in the liver of diabetic mice.