Akademik Veri Yönetim Sistemi
Galenos Yayinevi, cilt.15, ss.203-208, 2015 (ESCI)
Objective: In this retrospective study, serum uric acid levels of patients with diabetes, diabetes and chronic renal failure, and chronic renal failure without diabetes were compared respectively. It was investigated if uric acid can be used as a risk factor in diabetic and nondiabetic patients as an indicator of cardiovascular risk. Methods: This trial involved 285 patients in total who applied to the nephrology and internal medicine clinics or the hospital who were hospitalized in these clinics between 01.01.2013 and 31.03.2013. Retrospectively, last levels of creatinine, total protein, albumin, uric acid, total cholesterol, low density lipoprotein (LDL), high-density lipoprotein HDL cholesterol, plasma triglycerides, glucose, HbA1c, protein/creatinine ratio in spot urine sample and/or 24-hour urine protein belong to the patients assessed. Results: The mean age was 63.72 +/- 11.97 years in the patient groups. The patient count was 57 (20%) in the diabetes mellitus group (DM), 51 (17.9%) in the chronic renal failure group (KBY), and 177 (62.1%) in the chronic renal failure and diabetes group (KBY+DM). Mean uric acid levels were 5.72 +/- 1.96 mg/dL, 7.41 +/- 1.66mg/dL, and 7.20 +/- 1.72 mg/dL in these groups, respectively. In the groups divided to <1 gr/day, 1-3 gr/day and >3 gr/day according to their proteinuri levels, the uric acid levels were 6.83 +/- 1.92 mg/dL, 7.33 +/- 1.81 mg/dL, and 6.94 +/- 1.68 mg/dL, respectively. Conclusion: When the patient groups with proteinuria were analyzed, there was no significant difference between uric acid levels (p<0.05). In this status, hyperuricemia does not provide foresight in addition to microvascular and macrovascular risk from proteinuria. When supposed that diabetes is equivalent to coronary artery disease, the average uric acid level of the patient group with only diabetes (DM) was significantly lower than in the other two groups (p<0.05).