Correlating 10-2 Visual Field Loss with Structural and Angiographic Parameters in Advanced Glaucoma

Atay Dinçer K., Karaatlı M., Özalp O., Şimşek T., Nongpiur M. E., Atalay E.

OPHTHALMOLOGY AND THERAPY, cilt.14, sa.8, ss.1955-1964, 2025 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 8
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s40123-025-01192-1
  • Dergi Adı: OPHTHALMOLOGY AND THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Directory of Open Access Journals
  • Sayfa Sayıları: ss.1955-1964
  • Anahtar Kelimeler: Advanced glaucoma, Ganglion cell complex, Oct angiography, RNFL, Vessel density, Visual field
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

IntroductionWe investigated the relationship between optical coherence tomography (OCT) angiography (OCTA)-derived vascular parameters, central visual field (10-2 VF), ganglion cell complex (GCC), and retinal nerve fiber layer (RNFL) thickness in patients with advanced glaucoma.MethodsThis retrospective, cross-sectional study included 28 eyes of 23 patients with advanced glaucoma (VF mean deviation [MD] worse than - 12 dB on 24-2 testing). All participants underwent comprehensive ophthalmic examinations, OCT, OCTA, and 10-2 VF tests. Pearson's correlation was used to assess relationships between structural, functional, and vascular parameters.ResultsStatistically significant positive correlations were found between GCC thickness and 10-2 VF MD (r = 0.529, p = 0.005), and between parafoveal superficial capillary plexus vessel density (SCP-VD) and 10-2 VF MD (r = 0.549, p = 0.002). Macular SCP vessel area density showed a positive correlation with RNFL thickness (r = 0.429, p = 0.036). Mean vessel length in the optic nerve head layer exhibited a negative correlation with 10-2 VF MD (r = - 0.528, p = 0.003). Quadrant-wise analysis revealed positive associations between SCP-VD and both GCC (r = 0.409, p = 0.038) and RNFL thickness (r = 0.410, p = 0.047) in the superior hemifield, and between deep capillary plexus vessel density and RNFL thickness (r = 0.533, p = 0.007) in the inferior hemifield.ConclusionParafoveal SCP-VD and GCC thickness, due to their significant correlations with 10-2 VF MD, may serve as surrogate markers for monitoring central visual function and disease progression in advanced glaucoma, particularly when reliable VF testing is not feasible.