Urine and serum ghrelin, sCD80 and sCTLA-4 levels in doxorubicin-induced experimental nephrotic syndrome
INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.48, no.7, pp.1187-1196, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 48 Issue: 7
- Publication Date: 2016
- Doi Number: 10.1007/s11255-016-1249-4
- Journal Name: INTERNATIONAL UROLOGY AND NEPHROLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1187-1196
- Keywords: Ghrelin, sCD80, sCTLA-4, Nephrotic syndrome, MINIMAL-CHANGE DISEASE, KIDNEY-DISEASE, MICRORNAS, INJURY, DIET, RATS
- Eskisehir Osmangazi University Affiliated: Yes
Abstract
Nephrotic syndrome (NS) is an immune-mediated disorder associated with hyperlipidemia. NS has been proposed to be mediated through CD80-related T cell immune response, which could be blocked using soluble cytotoxic T lymphocyte-associated s(CTLA)-4. Although ghrelin is a hormone-modulating lipid metabolism and suppressing immune system, the precise role of ghrelin in NS is not well established.