Urine and serum ghrelin, sCD80 and sCTLA-4 levels in doxorubicin-induced experimental nephrotic syndrome

Ozkorucu D., ÇETİN N., Sav N. M., Yildiz B.

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.48, sa.7, ss.1187-1196, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 7
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s11255-016-1249-4
  • Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1187-1196
  • Anahtar Kelimeler: Ghrelin, sCD80, sCTLA-4, Nephrotic syndrome, MINIMAL-CHANGE DISEASE, KIDNEY-DISEASE, MICRORNAS, INJURY, DIET, RATS
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Nephrotic syndrome (NS) is an immune-mediated disorder associated with hyperlipidemia. NS has been proposed to be mediated through CD80-related T cell immune response, which could be blocked using soluble cytotoxic T lymphocyte-associated s(CTLA)-4. Although ghrelin is a hormone-modulating lipid metabolism and suppressing immune system, the precise role of ghrelin in NS is not well established.