Conventional and Molecular Cytogenetic Analyses in Turkish Patients with Multiple Myeloma

DURAK ARAS B., Akay O. M., Sungar G., Bademci G., Aslan V., Caferler J., ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.29, sa.2, ss.135-142, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5152/tjh.2011.42
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.135-142
  • Anahtar Kelimeler: Cytogenetcis, Myeloma, FISH, Chromosomal aberrations, IN-SITU HYBRIDIZATION, IGH TRANSLOCATIONS, INTERPHASE FISH, GENETIC ABNORMALITIES, ABERRATIONS, SURVIVAL, DELETIONS, RELEVANT, LEUKEMIA, 13Q
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: Multiple myeloma (MM) is characterized by the accumulation and proliferation of malignant plasma cells, secreting monoclonal immunoglobulins and genetic abnormalities in MM have implications for disease progression and survival. In the present study, we investigated the frequency of chromosomal abnormalities (CA) in Turkish patients with MM, using interphase FISH and CC and evaluated the relationship between the rearrangements detected, prognosis and stage of disease.