Conventional and Molecular Cytogenetic Analyses in Turkish Patients with Multiple Myeloma

DURAK ARAS B., Akay O. M., Sungar G., Bademci G., Aslan V., Caferler J., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.29, no.2, pp.135-142, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.5152/tjh.2011.42
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.135-142
  • Keywords: Cytogenetcis, Myeloma, FISH, Chromosomal aberrations, IN-SITU HYBRIDIZATION, IGH TRANSLOCATIONS, INTERPHASE FISH, GENETIC ABNORMALITIES, ABERRATIONS, SURVIVAL, DELETIONS, RELEVANT, LEUKEMIA, 13Q
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Objective: Multiple myeloma (MM) is characterized by the accumulation and proliferation of malignant plasma cells, secreting monoclonal immunoglobulins and genetic abnormalities in MM have implications for disease progression and survival. In the present study, we investigated the frequency of chromosomal abnormalities (CA) in Turkish patients with MM, using interphase FISH and CC and evaluated the relationship between the rearrangements detected, prognosis and stage of disease.