Akademik Veri Yönetim Sistemi
FRESENIUS ENVIRONMENTAL BULLETIN, cilt.20, ss.244-252, 2011 (SCI-Expanded)
Symbiotic microorganisms isolated from animals and plants have been shown to be a potential new source for antimicrobial substances. In this study, we screened antimicrobial activity of metabolites belonging to endosymbiotic endospore-forming bacteria isolated from various plants and animals (11 plants and 20 animals; epiphytic, rhizosphere, leaves and seeds, gut and feces). A total of 48 endospore-forming bacilli were investigated in two steps by agar piece and disc diffusion methods regarding their capacity to produce bioactive metabolites. Antibacterial activity of endospore-forming bacilli was assessed against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE) and Acinetobacter baumanii (clinic isolate). During the first screening, almost all of the isolates exhibited inhibitory effects against at least one test bacterium while one of the isolates also possessed inhibitory activity against all 3 tested organisms. As for the second screening, 19 isolates showed activity against MRSA, VRE, and Ac. baumanii. 2PaB1 and 15AaN2 isolates showed the highest activity against MRSA while 32AaB2 isolate showed good activity against all of the tested bacteria.