Primary unknown solitary brain metastasis: brain recurrence alone

Bayir Angin G., SAYNAK M., KOÇAK Z., ÖZEN A., Alas R. C., Caloglu V. Y., ...More

TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY, vol.22, no.2, pp.82-87, 2007 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 2
  • Publication Date: 2007
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.82-87
  • Keywords: Solitary brain metastasis, surgery, radiosurgery, unknown primary tumour, whole brain radiotherapy
  • Eskisehir Osmangazi University Affiliated: No


A 53-year-old male patient presented with complaints of headache and paresis in left arm. Cranial computerized tomography and magnetic resonance imaging (MRI) demonstrated a mass in the right parietal region. The solitary tumor was removed by craniotomy. Histological examination showed that it was a squamous cell carcinoma metastasis. The patient subsequently underwent whole brain radiotherapy for a total dose of 30 Gy in 10 fractions and conventional external-beam boost irradiation of 10 Gy in 5 fractions to the tumor margins. He remained disease free until 23 months later. He returned to our clinic with left arm paresis after 24 months. In the left parietal lobe a new lesion was determined on his MRI scan. Partial brain reirradiation at a dose of 25 Gy in 10 fractions was performed. There was a partial regression of symptoms after radiotherapy. In the light of this patient, we reviewed the literature and discussed the treatment strategies of patients with solitary brainmetastasis.