This research was conducted to determine depression symptom frequency in health sciences students (n = 445), to investigate sleep quality and some related factors. In this study of the students approximately one fifth of the students showed depressive symptom. Students with poor academic performance, poor economic status, smoking or alcohol use, chronic illness or mental problems are more likely to experience depression. As sleep quality deteriorates, the level of depression also increases. The risk of depressive symptoms in students with poor sleep quality was 3.28 times.