The effect of testosterone level on metabolic syndrome: a cross-sectional study.

Gucenmez S., Yildiz P., Donderici O., Serter R.

Hormones (Athens, Greece), vol.23, no.1, pp.163-169, 2024 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 1
  • Publication Date: 2024
  • Doi Number: 10.1007/s42000-023-00507-w
  • Journal Name: Hormones (Athens, Greece)
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.163-169
  • Keywords: Metabolic syndrome, Sex hormones, Testosterone
  • Eskisehir Osmangazi University Affiliated: Yes


Background Metabolic syndrome (MS) may reduce circulating testosterone and, at the same time, low testosterone levels may lead to MS. Thus, identifying problems regarding sex hormones and examining their effects on the pathogenesis of MS is important to prevent serious complications of the condition, such as diabetes or cardiovascular diseases.AimsThis study aimed to investigate the correlations between MS-related parameters and androgen levels.Methods A total of 108 males [median age 48.5 years (min/max = 21/77 years)] were included in the study. Blood pressure and anthropometric measurements (body mass index, waist circumference, hip circumference, thigh circumference, neck circumference, and length of index and ring finger) were performed. Biochemical analysis was assessed. Additionally, total testosterone, free testosterone, and sex hormone binding globulin levels were investigated.Results Weak negative correlations were observed between testosterone levels and several anthropometric measures/glucose metabolisms (p < 0.05). The highest correlation was between total testosterone levels and body mass index (rho= -0.390, p < 0.001)Conclusion According to our results, controlling weight, one of the preventable risk factors, can have a positive effect on testosterone levels and, therefore, on the cardiovascular system through different mechanisms.