What is the significance of non-specific pleuritis? A trick question

Janssen J., Maldonado F., METİNTAŞ M.

CLINICAL RESPIRATORY JOURNAL, vol.12, no.9, pp.2407-2410, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 9
  • Publication Date: 2018
  • Doi Number: 10.1111/crj.12940
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2407-2410
  • Keywords: cancer, malignant pleural effusion, mesothelioma, pleural effusion, thoracoscopy, PLEURAL EFFUSIONS, THORACOSCOPY
  • Eskisehir Osmangazi University Affiliated: Yes


Non-specific pleuritis (NSP) is defined as fibrinous or inflammatory pleuritis which cannot be attributed to a specific benign or malignant etiology. It can be diagnosed in biopsies in up to 30% of cases of exudative pleuritis after thoracoscopy, with a mean of 19.2%. In 66 out of 469 (14.2%) patients in combined series, a malignant pleural disease (mostly mesothelioma) was found during a follow-up of at least 21months. Most likely, a follow-up time of 12months is sufficient, although the current routine is a follow-up of 2years. Because of a benign course in 85% of patients with NSP, a repeated invasive procedure after thoracoscopy is only indicated in a limited group of patients. The most important indications for a repeated pleural biopsy are persistent chest pain, recurrent pleural effusion, radiologic findings suggestive for malignant pleural disease.